Leukocyte ABCA1 impedes progression of established atherosclerotic lesions after dietary cholesterol lowering in LDLr-/- mice
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منابع مشابه
Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr−/− Mice Compared to Nondiabetic LDLr−/− Mice
BACKGROUND Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood. One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation. The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of a...
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Vincent Braunersreuther, Sabine Steffens, Claire Arnaud, Graziano Pelli, Fabienne Burger, in Mice A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2008 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arterio...
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متن کاملMacrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.
BACKGROUND ATP-binding cassette transporter A1 (ABCA1) is a key regulator of cellular cholesterol and phospholipid transport. Previously, we have shown that inactivation of macrophage ABCA1 induces atherosclerosis in low-density lipoprotein receptor knockout (LDLr-/-) mice. However, the possibly beneficial effects of specific upregulation of macrophage ABCA1 on atherogenesis are still unknown. ...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2017
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2017.06.033